CGRP pathway monoclonal antibodies

The first preventive medication dedicated to treating migraine

These are the newest preventive medicines specifically developed and licenced for the treatment of migraine. Most of the current preventive medicines used to treat migraine have been developed for other conditions. This is therefore an exciting development for migraine sufferers.

How they work

Migraine is a brain disorder. During a migraine attack the cerebral nerves and blood vessels release substances including Calcitonin Gene-Related Peptide (CGRP). CGRP is a neuropeptide and has been implicated in different pain processes, including migraine. CGRP also functions as a vasodilator — that is, it relaxes blood vessels.

Research suggests that these substances are released during a migraine attack and play a significant role in developing and sustaining migraine.

The four CGRP monoclonal antibody (mAbs) treatments

CGRP compounds Erenumab  Aimovig (Novartis/Amgen) Fremanezumab Ajovy (Teva)

 

Galcanezumab Emgality (Eli Lilly) Eptinezumab  (Alder)
Availability in the UK Privately – not throughout NHS (available within NHS Scotland for chronic migraine) Privately – not on NHS Privately – not on NHS Due to be submitted for approval to be available in the UK
How  it is administered Subcutaneous injection once per month Subcutaneous injection once per month or every three months Subcutaneous injection once per month Intravenous injection once every three months

These four new compounds have been developed to either inactivate the CGRP molecule by binding to it or to block its receptor, to prevent migraine developing. Recent research conducted in thousands of people with migraine has demonstrated that these compounds are safe and effective in reducing migraine attacks and headache days.

None of the compounds are to be taken by mouth. This has the advantage of bypassing the gut, with possibly fewer side effects and the convenience of treating monthly or less. Three of these compounds are designed to be given by subcutaneous injection (just under the skin), once per month. The fourth, Eptinezumab will be given intravenously (into a vein by infusion), once every three months. The main side effects noted in the studies were associated injection site reactions.

Access to treatment

As with all new treatments, NICE (National Institute for Health and Care Excellence) and SMC (Scottish Medicine Consortium) will consider the evidence and affordability criteria to determine NHS patient access.  Aimovig (erenumab) is now available within NHS Scotland for chronic migraine patients and it is hoped that these treatments will be made available throughout the NHS to sufferers who get frequent migraines for which other medicines may not have worked. If you are struggling to manage your migraine and think you may benefit from this or another treatment, you should see your GP for a review and possible referral for treatment.